Neuroendocrine tumors (NETs) are a heterogeneous class of neoplasms arising from neuroendocrine cells that are scattered throughout the body.¹ Data from population-based registries indicate that the majority of NETs arise from the gastrointestinal tract, followed by lung and pancreas.¹ Although the incidence of these tumors is increasing, NETs have usually been considered a rare entity. The World Health Organization (WHO) 2010 classification systems for the gastroenteropancreatic NETs categorize tumors as well-differentiated NETs that can be divided into grade 1 (Ki67 < 3%) and grade 2 (Ki67 3–20%), and poorly differentiated neuroendocrine carcinomas (Ki-67 > 20%).² Radical surgery is the only curative treatment for NETs; however, only a low percentage of patients are suitable for surgery as more than 50% of patients have advanced disease at diagnosis.³

中文翻译：

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晚期神经内分泌肿瘤患者的治疗：网络荟萃分析

神经内分泌肿瘤 (NET) 是一种异质性肿瘤，起源于分散在全身的神经内分泌细胞。¹来自基于人群的登记数据表明，大多数 NET 来自胃肠道，其次是肺和胰腺。¹尽管这些肿瘤的发病率正在增加，但 NET 通常被认为是一种罕见的实体。世界卫生组织 (WHO) 2010 年胃肠胰腺 NET 分类系统将肿瘤分类为高分化 NET，可分为 1 级 (Ki67 < 3%) 和 2 级 (Ki67 3-20%)，以及低分化神经内分泌癌(Ki-67 > 20%)。²根治性手术是 NET 的唯一治愈方法；然而，只有一小部分患者适合手术，因为超过 50% 的患者在诊断时患有晚期疾病。³