Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases.

中文翻译：

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人体组织中的体细胞突变和克隆扩增。


最近对健康皮肤和食道的测序研究发现，随着年龄的增长，这些组织会被携带传统癌症基因驱动突变的细胞突变克隆定植。本评论总结了这些发现，并讨论了它们对我们理解癌症、衰老和其他疾病的可能影响。