White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss.

中文翻译：

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一项为期 24 个月的体育锻炼计划对有阿尔茨海默病风险的老年人大脑变化的影响：AIBL Active 试验

白质高信号 (WMH) 是认知能力下降的危险因素。体力活动 (PA) 与较低的 WMH 相关。长期接受 PA 计划是否对患有记忆障碍和合并症的老年人的 WMH 进展有有益影响的探索有限。本研究探讨了 24 个月的中等强度 PA 干预是否可以延缓有认知能力下降风险的老年人的 WMH 和海马损失的进展。在磁共振成像上获得的数据用于测量 WMH 和海马体丢失的进展。这项研究的结果显示干预对主要结果指标“WMH”或次要结果指标“海马体积”没有影响。此外，β 淀粉样蛋白状态和对干预的依从性都对结果没有任何影响。在这一具有血管危险因素的主观记忆主诉和轻度认知障碍参与者队列中，长期中等强度的 PA 对 WMH 或海马损失没有影响。