It is shown that the tendency of an archetypal antimicrobial peptide to insert into and perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The results, obtained through molecular dynamics simulations, have been demonstrated with several lipid compositions and appear to be general, although quantitative details differ. The findings imply that the potency of antimicrobial peptides may not be a purely intrinsic chemical property and, instead, depends on the mechanical state of the target membrane.

中文翻译：

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应激脂质双层中抗菌肽效能的调节。

已经表明，原型抗微生物肽插入并穿透简单脂质双层的趋势受到膜中拉应力的强烈调节。通过分子动力学模拟获得的结果已经用几种脂质组成得到了证明，尽管定量细节不同，但结果似乎是通用的。该发现暗示抗微生物肽的效力可能不是纯粹内在的化学性质，而是取决于靶膜的机械状态。