Organelles were originally considered to be individual cellular compartments with a defined organization and function. However, recent studies revealed that organelles deeply communicate within each other via Ca2+ exchange. This communication, mediated by specialized membrane regions in close apposition between two organelles, regulate cellular functions, including metabolism and cell fate decisions. Advances in microscopy techniques, molecular biology and biochemistry have increased our understanding of these interorganelle platforms. Research findings suggest that interorganellar Ca2+ signaling, which is altered in cancer, influences tumorigenesis and tumor progression by controlling cell death programs and metabolism. Here, we summarize the available data on the existence and composition of interorganelle platforms connecting the endoplasmic reticulum with mitochondria, the plasma membrane, or endolysosomes. Finally, we provide a timely overview of the potential function of interorganellar Ca2+ signaling in maintaining cellular homeostasis.

中文翻译：

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细胞间钙信号传导在细胞代谢调节中的应用：癌症的观点。

细胞器最初被认为是具有定义的组织和功能的单个细胞室。但是，最近的研究表明，细胞器之间通过Ca2 +交换相互深入交流。这种通讯由两个细胞器之间紧密并置的专门膜区域介导，调节细胞功能，包括新陈代谢和细胞命运决定。显微镜技术，分子生物学和生物化学的进步增加了我们对这些有机器官平台的理解。研究发现表明，在癌症中改变的细胞间Ca 2+信号传导通过控制细胞死亡程序和新陈代谢来影响肿瘤发生和肿瘤进展。这里，我们总结了有关连接内质网与线粒体，质膜或内溶酶体的细胞间平台的存在和组成的可用数据。最后，我们提供了有关组织间Ca2 +信号传导在维持细胞稳态中潜在功能的及时概述。