The latest breakthrough towards the adequate and decisive methods of gene editing tools provided by CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR Associated System), has been repurposed into a tool for genetically engineering eukaryotic cells and now considered as the major innovation in gene-related disorders. Nanotechnology has provided an alternate way to overcome the conventional problems where methods to deliver therapeutic agents have failed. The use of nanotechnology has the potential to safe-side the CRISPR/Cas9 components delivery by using customized polymeric nanoparticles for safety and efficacy. The pairing of two (CRISPR/Cas9 and nanotechnology) has the potential for opening new avenues in therapeutic use. In this review, we will discuss the most recent advances in developing nanoparticle-based CRISPR/Cas9 gene editing cargo delivery with a focus on several polymeric nanoparticles including fabrication proposals to combat microbial infections.

中文翻译：

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基于CRISPR / Cas9的聚合物纳米颗粒，用于治疗/抑制微生物感染。

CRISPR / Cas9（聚簇有规律间隔的短回文重复/ CRISPR关联系统）所提供的基因编辑工具的适当性和决定性方法的最新突破，已被重新用于基因工程真核细胞的工具，现已被认为是基因改造工具中的重大创新基因相关疾病。纳米技术提供了另一种方法来克服传统的问题，在这些问题中，输送治疗剂的方法失败了。纳米技术的使用有可能通过使用定制的聚合物纳米粒子来确保CRISPR / Cas9组件的递送安全性和有效性。两者的配对（CRISPR / Cas9和纳米技术）有可能为治疗用途开辟新的途径。在这篇评论中，