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A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression
Immunity ( IF 25.5 ) Pub Date : 2019-05-21 , DOI: 10.1016/j.immuni.2019.04.008
Dan Wu , Megan K. Levings

Little is known about how Treg cells mediate suppression, especially in tissues. In this issue of Immunity, Schmidleithner et al. report that Treg cells catabolize PGE2 into 15-keto-PGE2, a T cell-inhibitory metabolite, and that this mechanism controls inflammation in adipose tissue.



中文翻译:

在人类和小鼠Treg细胞中的新作用机理:抑制Ke(y)

关于Treg细胞如何介导抑制作用,尤其是在组织中,人们所知甚少。在《免疫》一书中,施密德纳(Schmidleithner)等人 报告指出,Treg细胞将PGE 2分解代谢为15-酮-PGE 2(一种抑制T细胞的代谢物),并且这种机制控制了脂肪组织中的炎症。

更新日期:2019-05-21
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