Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi's Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case-control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and -DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.

中文翻译：

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人白细胞抗原等位基因与喀麦隆卡波济肉瘤风险之间的关系。

迄今为止，已有几项研究报告了人类白细胞抗原（HLA）等位基因与不同类型的卡波济肉瘤（KS）之间的关联。但是，确定的HLA等位基因与研究人群之间几乎没有一致性。为了在喀麦隆病例对照研究中检验HLA等位基因是否与KS相关，我们在KSHV血清反应阳性的个体中进行了高分辨率HLA分型。在HIV阳性个体中，HLA-B * 14：01的携带者患AIDS-KS的风险明显更高（p = 0.033）。对于HIV阴性患者，等位基因频率的基因方式比较确定了HLA-B（p = 0.008）和-DQA1（p = 0.002）基因座是地方性KS的可能危险因素。我们的研究为KS的遗传决定因素及其在疾病发病机理中的意义提供了额外的理解。