Molecularly Imprinted Nanoparticles for Biomedical Applications.,Advanced Materials

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Molecularly Imprinted Nanoparticles for Biomedical Applications.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-05-15 , DOI: 10.1002/adma.201806328
Huiqi Zhang ₁

Affiliation

Molecularly imprinted polymers (MIPs) are synthetic receptors with tailor-made recognition sites for target molecules. Their high affinity and selectivity, excellent stability, easy preparation, and low cost make them promising substitutes to biological receptors in many applications where molecular recognition is important. In particular, spherical MIP nanoparticles (or nanoMIPs) with diameters typically below 200 nm have drawn great attention because of their high surface-area-to-volume ratio, easy removal of templates, rapid binding kinetics, good dispersion and handling ability, undemanding functionalization and surface modification, and their high compatibility with various nanodevices and in vivo biomedical applications. Recent years have witnessed significant progress made in the preparation of advanced functional nanoMIPs, which has eventually led to the rapid expansion of the MIP applications from the traditional separation and catalysis fields to the burgeoning biomedical areas. Here, a comprehensive overview of key recent advances made in the preparation of nanoMIPs and their important biomedical applications (including immunoassays, drug delivery, bioimaging, and biomimetic nanomedicine) is presented. The pros and cons of each synthetic strategy for nanoMIPs and their biomedical applications are discussed and the present challenges and future perspectives of the biomedical applications of nanoMIPs are also highlighted.

中文翻译：

用于生物医学应用的分子印迹纳米颗粒。

分子印迹聚合物（MIP）是具有针对目标分子的量身定制识别位点的合成受体。它们的高亲和力和选择性，出色的稳定性，易于制备和成本低廉，使其成为在许多重要的分子识别应用中有望取代生物受体的生物。特别是，直径通常低于200 nm的球形MIP纳米颗粒（或nanoMIPs）因其高的表面积/体积比，易于移除的模板，快速的结合动力学，良好的分散和处理能力，不需要的功能化而备受关注。表面改性以及它们与各种纳米器件和体内生物医学应用的高度兼容性。近年来，先进的功能性nanoMIP的制备取得了重大进展，最终导致MIP应用从传统的分离和催化领域迅速发展到新兴的生物医学领域。在这里，将概述在nanoMIP制备及其重要的生物医学应用（包括免疫测定，药物递送，生物成像和仿生纳米医学）方面取得的最新进展。讨论了nanoMIPs及其生物医学应用的每种合成策略的利弊，并着重介绍了nanoMIPs的生物医学应用的当前挑战和未来前景。介绍了在制备nanoMIP及其重要的生物医学应用（包括免疫测定，药物递送，生物成像和仿生纳米医学）方面取得的最新进展的全面概述。讨论了每种合成策略对nanoMIP及其生物医学应用的利弊，并着重指出了nanoMIP的生物医学应用的当前挑战和未来前景。介绍了在制备nanoMIP及其重要的生物医学应用（包括免疫测定，药物递送，生物成像和仿生纳米医学）方面取得的最新进展的全面概述。讨论了每种合成策略对nanoMIP及其生物医学应用的利弊，并着重指出了nanoMIP的生物医学应用的当前挑战和未来前景。

更新日期：2020-01-22

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