The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate γδ T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.

中文翻译：

---

过敏性接触性皮炎的转变模式：先天免疫的作用。


先天免疫系统在过敏性接触性皮炎（ACD）中的作用传统上仅限于初始抗原致敏阶段。然而，最近的研究结果表明先天免疫在 ACD 的其他方面发挥着作用，包括经典 IV 型超敏反应的效应阶段。因此，介导 ACD 的精确免疫机制比之前认为的更为复杂。本综述的目的是深入了解先天免疫系统在 ACD 发病机制中的作用的最新进展，包括巨噬细胞、先天淋巴细胞、自然杀伤细胞、先天 γδ​​ T 细胞和其他信号传导的新机制作用分子。这些见解为 ACD 的治疗干预提供了新的机会。