BACKGROUND & AIMS Increased gut permeability might contribute to the pathogenesis of irritable bowel syndrome or functional abdominal pain (IBS or FAP). We investigated whether siblings and parents of children with IBS or FAP have increased gut permeability. METHODS We performed permeability tests (using sucrose, lactulose, mannitol, and sucralose) on 29 siblings and 43 parents of children with IBS or FAP, and 43 children (controls) and 42 parents of controls, from primary and secondary care. Permeability studies were repeated in 7 siblings and 37 parents of children with IBS or FAP and 23 controls and 36 parents of controls following ingestion of 400 mg of ibuprofen. Percent recovery of sucrose was calculated based on analyses of urine collected overnight; the lactulose/mannitol ratio and percent recovery of sucralose were based on analyses of urine samples collected over a 24-hour period. RESULTS When we controlled for age, sex, and family membership, siblings of children with IBS or FAP had increased small bowel permeability (urinary lactulose/mannitol ratio) vs controls (P = .004). There was no difference in gastroduodenal (percent sucrose recovery) or colonic (percent sucralose recovery) permeability between groups. Similarly, parents of children with IBS or FAP also had increased small bowel permeability, compared with parents of controls (P = .015), with no differences in gastric or colonic permeability. After administration of ibuprofen, gastroduodenal and small bowel permeability tended to be greater in IBS or FAP siblings (P = .08) and gastroduodenal permeability tended to be greater in IBS or FAP parents (P = .086). CONCLUSIONS Siblings and parents of children with IBS or FAP have increased baseline small intestinal permeability compared with control children and their parents. These results indicate that there are familial influences on gastrointestinal permeability in patients with IBS or FAP.

中文翻译：

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肠易激综合征或功能性腹痛儿童一级亲属的肠道通透性增加。

背景和目的 肠道通透性增加可能导致肠易激综合征或功能性腹痛（IBS 或 FAP）的发病机制。我们调查了 IBS 或 FAP 儿童的兄弟姐妹和父母是否增加了肠道通透性。方法 我们对来自初级和二级医疗机构的 29 名 IBS 或 FAP 儿童的 29 名兄弟姐妹和 43 名父母，以及 43 名儿童（对照组）和 42 名对照组的父母进行了渗透性测试（使用蔗糖、乳果糖、甘露醇和三氯蔗糖）。在摄入 400 毫克布洛芬后，对 7 名兄弟姐妹和 37 名 IBS 或 FAP 儿童的父母以及 23 名对照者和 36 名对照者的父母重复了渗透性研究。基于对过夜收集的尿液的分析计算蔗糖的回收百分比；乳果糖/甘露醇的比例和三氯蔗糖的回收率基于对 24 小时内收集的尿液样本的分析。结果 当我们控制年龄、性别和家庭成员时，与对照组相比，IBS 或 FAP 儿童的兄弟姐妹小肠通透性增加（尿乳果糖/甘露醇比率）（P = .004）。两组之间的胃十二指肠（蔗糖回收百分比）或结肠（三氯蔗糖回收百分比）通透性没有差异。同样，与对照组的父母相比，IBS 或 FAP 儿童的父母小肠通透性也增加（P = .015），胃或结肠通透性没有差异。服用布洛芬后，IBS 或 FAP 同胞的胃十二指肠和小肠通透性往往更高（P = . 08) 和胃十二指肠通透性在 IBS 或 FAP 父母中往往更大 (P = .086)。结论 与对照组儿童及其父母相比，IBS 或 FAP 儿童的兄弟姐妹和父母的基线小肠通透性增加。这些结果表明，IBS 或 FAP 患者的胃肠道通透性存在家族性影响。