Mitochondria are essential organelles required for cellular processes ranging from energy production to cellular differentiation. To perform these functions, mitochondria physically and functionally interact with other organelles such as the endoplasmic reticulum (ER) and endosomes. While the role of ER-mitochondria contact sites is well established, the interaction between mitochondria and endosomes has only recently been reported. These interactions are involved in lipid and ion transfer and potentially play a crucial role in mitochondria quality control and the release of mitochondrial components within extracellular vesicles. Here, we will discuss the current view of mitochondria-endosome interaction, both physically and functionally.

中文翻译：

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内吞作用和线粒体转移中线粒体与内体区室的相互作用

线粒体是从能量产生到细胞分化的细胞过程所需的重要细胞器。为了执行这些功能，线粒体在物理上和功能上与内质网 (ER) 和内体等其他细胞器相互作用。虽然 ER-线粒体接触位点的作用已经很好地确立，但最近才报道了线粒体和内体之间的相互作用。这些相互作用涉及脂质和离子转移，并可能在线粒体质量控制和细胞外囊泡内线粒体成分的释放中发挥关键作用。在这里，我们将在物理和功能上讨论线粒体-内体相互作用的当前观点。