Helicases are enzymes that move, manage, and manipulate nucleic acids. They can be subdivided into six super families and are required for all aspects of nucleic acid metabolism. In general, all helicases function by converting the chemical energy stored in the bond between the gamma and beta phosphates of adenosine triphosphate into mechanical work, which results in the unidirectional movement of the helicase protein along one strand of a nucleic acid. The results of this translocation activity can range from separation of strands within duplex nucleic acids to the physical remodeling or removal of nucleoprotein complexes. In this review, we focus on describing key helicases from the model organism Saccharomyces cerevisiae that contribute to the regulation of homologous recombination, which is an essential DNA repair pathway for fixing damaged chromosomes.

中文翻译：

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酿酒酵母同源重组期间的解旋酶机制。

解旋酶是移动，管理和操纵核酸的酶。它们可以细分为六个超家族，是核酸代谢各个方面所必需的。通常，所有解旋酶通过将存储在三磷酸腺苷的γ和β磷酸之间的键中的化学能转化为机械功而起作用，这导致解旋酶蛋白沿着核酸的一条链单向运动。这种移位活性的结果可以从双链核酸内的链分离到核蛋白复合物的物理重塑或去除。在这篇综述中，我们重点介绍来自模型生物酿酒酵母的关键解旋酶，这些酶有助于调节同源重组，