The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan signaling is enticing as a reservoir of potential drug targets and prospects for novel therapeutic strategies. The newest trend in proteoglycan biology is the interplay between extracellular signaling and autophagy fueled by the close link between autophagy and angiogenesis. Here we summarize the most current evidence surrounding proteoglycan signaling in both of these biological processes featuring the well-known suspects, decorin and perlecan, as well as other up-and-coming neophytes in this evolving signaling web.

对更有效的癌症疗法的需求无处不在，因为肿瘤生物学的复杂性和高度适应性机制使这种疾病甚至可以逃避最严格的治疗选择。蛋白多糖信号传导领域不断扩大，作为潜在药物靶标的储库和新治疗策略的前景非常诱人。蛋白多糖生物学的最新趋势是细胞外信号和自噬之间的相互作用，这是由自噬和血管生成之间的密切联系推动的。在这里，我们总结了关于这两个生物过程中蛋白聚糖信号的最新证据，其中包括众所周知的核心蛋白聚糖和珍珠聚糖，以及这个不断发展的信号网络中其他崭露头角的新手。