Since its description by Widal in 1922 and Max Samter in 1967, significant efforts have been made to understand the molecular underpinnings of NSAID-exacerbated respiratory disease (NERD), which comprises the pathognomonic triad of asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and respiratory sensitivity to NSAID ingestion.[1] An intriguing aspect of this syndrome is that it is typically acquired in adulthood and only a minority of patients with nasal polyps, asthma or both conditions has sensitivity to NSAIDs. These observations would suggest the pathogenesis is neither a germ line metabolic syndrome nor a synergistic systemic manifestation of the component respiratory ailments. This article is protected by copyright. All rights reserved.

中文翻译：

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NERD y 嗜酸性粒细胞是否会加速鼻息肉生长？

自从 Widal 于 1922 年和 Max Samter 于 1967 年对其进行描述以来，已经做出了重大努力来了解 NSAID 加重性呼吸系统疾病 (NERD) 的分子基础，其中包括哮喘、慢性鼻窦炎伴鼻息肉 (CRSwNP) 和对 NSAID 摄入的呼吸敏感性。 [1] 这种综合征的一个有趣方面是它通常在成年期获得，并且只有少数患有鼻息肉、哮喘或两者都有的患者对 NSAID 敏感。这些观察结果表明发病机制既不是种系代谢综合征，也不是组成呼吸系统疾病的协同全身表现。本文受版权保护。版权所有。