Besides their metabolic and endocrine functions, the growth hormone (GH) and its mediated factor, the insulin‐like growth factor I (IGF‐I), have been implicated in different brain functions, including neurogenesis. Long‐lasting elevated GH and IGF‐I levels result in non‐reversible somatic, endocrine and metabolic morbidities. However, the subcutaneous implantation of the GH‐secreting (GH‐S) GC cell line in rats leads to the controllable over‐secretion of GH and elevated IGF‐I levels, allowing the experimental study of their short‐term effects on brain functions.

中文翻译：

---

成年生长激素/ IGF-I过度分泌的慢性成年发作可改善成年大鼠的认知功能和LTP，并促进神经元分化。

除了其代谢和内分泌功能外，生长激素（GH）及其介导因子胰岛素样生长因子I（IGF-I）还与包括神经发生在内的不同脑功能有关。长期升高的GH和IGF-I水平会导致不可逆的体细胞，内分泌和代谢疾病。然而，在大鼠中皮下植入生长激素分泌（GH-S）GC细胞系可导致生长激素的可控过度分泌和IGF-I水平升高，从而可以进行其对脑功能的短期影响的实验研究。