The nature of the tumor antigens that are detectable by T cells remains unclear. In melanoma, T cells were shown to react against major histocompatibility complex (MHC)-associated peptides (MAPs) that are derived from exonic mutations. A recent multi-omic study of hepatocellular carcinomas suggests, however, that mutated exonic MAPs were exceedingly rare, bringing the accuracy of the current methods for antigen identification into question and demonstrating the importance of broadening tumor-antigen discovery efforts.

中文翻译：

---

可作用肿瘤抗原的发现和表征。

T 细胞可检测到的肿瘤抗原的性质仍不清楚。在黑色素瘤中，T 细胞可与源自外显子突变的主要组织相容性复合体 (MHC) 相关肽 (MAP) 发生反应。然而，最近的一项肝细胞癌多组学研究表明，突变的外显子 MAP 极其罕见，这使当前抗原鉴定方法的准确性受到质疑，并证明了扩大肿瘤抗原发现工作的重要性。