高氯酸钠可引起发育不全的棘背性非酒精性脂肪肝疾病。,Environmental Pollution

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高氯酸钠可引起发育不全的棘背性非酒精性脂肪肝疾病。
Environmental Pollution ( IF 8.9 ) Pub Date : 2019-05-02 , DOI: 10.1016/j.envpol.2019.05.001
Michael R Minicozzi ₁ , Frank A von Hippel ₁ , Christoff G Furin ₂ , C Loren Buck ₁

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高氯酸盐是一种普遍存在的水溶性污染物，可竞争性地抑制钠/碘化物的转运体，从而减少了可用于甲状腺激素合成的碘化物。碘摄入不足会导致甲状腺功能减退和代谢综合征。由于新陈代谢，肥胖症和非酒精性脂肪肝疾病（NAFLD）紧密相关，因此我们假设高氯酸盐将作为肥胖源，并通过发育中的三脊椎棘背le（Gasterosteus aculeatus）肝脏中脂质的积累而引起NAFLD。我们在两种浓度（30 mg / L和100 mg / L）加上对照（0 mg / L）的棘背胚胎上进行了升/降档暴露方案（从纯水到高氯酸盐处理过的水或从高氯酸盐到水处理过的净水） 305天的过程。安乐死了成人棘背动物，H＆E染色并分析肝形态。具体来说，我们计算了脂质滴的数量，并测量了每个滴的面积和肝脏代表性切片的总脂质面积。我们发现，与对照鱼相比，用高氯酸盐处理的鱼在肝脏中具有更多和更大的脂滴，并且肝脏中的脂百分比更高。这些数据表明，高氯酸盐会在受污染部位常见的浓度下引起棘背型NAFLD和肝脂肪变性。这些数据还表明高氯酸盐有可能成为致肥胖物。未来的研究应通过检查器官的特定脂质蓄积以及高氯酸盐是否以饮用水中常见浓度引起这些影响，来研究高氯酸盐的致肥胖能力。

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Sodium perchlorate induces non-alcoholic fatty liver disease in developing stickleback.

Perchlorate is a pervasive, water-soluble contaminant that competitively inhibits the sodium/iodide symporter, reducing the available iodide for thyroid hormone synthesis. Insufficient iodide uptake can lead to hypothyroidism and metabolic syndromes. Because metabolism, obesity and non-alcoholic fatty liver disease (NAFLD) are tightly linked, we hypothesized that perchlorate would act as an obesogen and cause NAFLD via accumulation of lipids in liver of developing threespine stickleback (Gasterosteus aculeatus). We performed an upshift/downshift exposure regime (clean water to perchlorate treated water or perchlorate treated water to clean water) on stickleback embryos at two concentrations (30 mg/L and 100 mg/L) plus the control (0 mg/L) over the course of 305 days. Adult stickleback were euthanized, H&E stained and analyzed for liver morphology. Specifically, we counted the number of lipid droplets, and measured the area of each droplet and the total lipid area of a representative section of liver. We found that perchlorate treated fish had more and larger lipid droplets, and a larger percentage of lipid in their liver than control fish. These data indicate that perchlorate causes NAFLD and hepatic steatosis in stickleback at concentrations commonly found at contaminated sites. These data also indicate the potential of perchlorate to act as an obesogen. Future studies should investigate the obesogenic capacity of perchlorate by examining organ specific lipid accumulation and whether perchlorate induces these effects at concentrations commonly found in drinking water. Work is also needed to determine the mechanisms by which perchlorate induces lipid accumulation.

更新日期：2019-05-02

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