BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) varies significantly across ethnic groups. A better understanding of the mechanisms underlying the variation in different ethnic groups may help to elucidate the pathophysiology of T2DM. The present work aims to generate a hypothesis regarding "why do subjects with African background have excess burden of T2DM?". METHODS In the current study, we performed metabolite profiling of plasma samples derived from 773 subjects of three ethnic groups (Dutch with European, Ghanaian and African Surinamese background). We performed Bayesian lognormal regression analyses to assess associations between HbA1c and circulating metabolites. RESULTS Here we show that subjects with African Surinamese and Ghanaian background had similar associations of HbA1c with circulating amino acids and triglyceride-rich lipoproteins as subjects with European background. In contrast, subjects with Ghanaian and African Surinamese background had different associations of HbA1c with acetoacetate, small LDL particle and small HDL particle concentrations, compared to the subjects with European background. CONCLUSIONS On the basis of the observations, we hypothesize that the excess burden of T2DM in subjects with African background may be due to impaired cholesterol efflux capacity or abnormal cholesterol uptake.

中文翻译：

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具有欧洲、非洲苏里南和加纳背景的荷兰人血红蛋白 A1C 与循环代谢物的关联。

背景 2 型糖尿病 (T2DM) 的患病率在不同种族群体中存在显着差异。更好地了解不同种族群体差异的机制可能有助于阐明 T2DM 的病理生理学。目前的工作旨在提出一个关于“为什么具有非洲背景的受试者有过多的 T2DM 负担？”的假设。方法 在本研究中，我们对来自三个民族（具有欧洲、加纳和非洲苏里南背景的荷兰人）的 773 名受试者的血浆样本进行了代谢物分析。我们进行了贝叶斯对数正态回归分析来评估 HbA1c 与循环代谢物之间的关联。结果在这里，我们表明，具有非洲苏里南和加纳背景的受试者与具有欧洲背景的受试者具有相似的 HbA1c 与循环氨基酸和富含甘油三酯的脂蛋白的相关性。相反，与具有欧洲背景的受试者相比，具有加纳和非洲苏里南背景的受试者的 HbA1c 与乙酰乙酸、小 LDL 颗粒和小 HDL 颗粒浓度的关联不同。结论 根据观察结果，我们假设非洲背景受试者 T2DM 负担过重可能是由于胆固醇流出能力受损或胆固醇摄取异常所致。