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The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions.
Annual Review of Immunology ( IF 26.9 ) Pub Date : 2018-11-28 , DOI: 10.1146/annurev-immunol-042718-041607
Craig N Morrell 1 , Daphne N Pariser 1 , Zachary T Hilt 1 , Denisse Vega Ocasio 1
Affiliation  

Platelets have dual physiologic roles as both cellular mediators of thrombosis and immune modulatory cells. Historically, the thrombotic function of platelets has received significant research and clinical attention, but emerging research indicates that the immune regulatory roles of platelets may be just as important. We now know that in addition to their role in the acute thrombotic event at the time of myocardial infarction, platelets initiate and accelerate inflammatory processes that are part of the pathogenesis of atherosclerosis and myocardial infarction expansion. Furthermore, it is increasingly apparent from recent studies that platelets impact the pathogenesis of many vascular inflammatory processes such as autoimmune diseases, sepsis, viral infections, and growth and metastasis of many types of tumors. Therefore, we must consider platelets as immune cells that affect all phases of immune responses.

中文翻译:

血小板拿破仑复合物小细胞,但免疫调节功能强。

血小板既具有血栓形成的细胞介质又具有免疫调节细胞的双重生理作用。从历史上看,血小板的血栓形成功能已经受到了重要的研究和临床关注,但是新兴的研究表明,血小板的免疫调节作用可能同样重要。我们现在知道,除了它们在心肌梗塞时在急性血栓形成事件中的作用外,血小板还引发和加速炎症过程,这是动脉粥样硬化和心肌梗塞扩大的发病机制的一部分。此外,从最近的研究中越来越明显的是,血小板影响许多血管炎性过程的发病机理,例如自身免疫性疾病,败血症,病毒感染以及许多类型肿瘤的生长和转移。所以,
更新日期:2020-04-21
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