The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.

中文翻译：

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T 细胞免疫突触肌动蛋白和肌动球蛋白网络的起源、组织、动力学和功能。


T 细胞与抗原呈递细胞 (APC) 或活化表面的结合导致 T 细胞内形成几种不同的肌动蛋白和肌动球蛋白网络。这些网络主要位于紧邻 T 细胞质膜下方的狭窄区域内，位于其与 APC 或激活表面接触的部位，即免疫突触处。在这里，我们回顾这些突触相关肌动蛋白和肌动球蛋白网络的起源、组织、动力学和功能。重要的是，最近通过光学显微镜的进步，在一些情况下对这些基于肌动蛋白的细胞骨架结构的性质的了解成为可能。