Plasmodium falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor-based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites.

中文翻译：

---

恶性疟原虫的抗体反应：疫苗设计和基于受体的抗体的发现线索。

由于病原体的复杂性和多样性，恶性疟原虫仍然是一个严重的公共卫生问题，也是免疫系统面临的持续挑战。几个实验室在表征对寄生虫的抗体反应方面的最新进展已导致鉴定了重要的保护靶标，并揭示了一种基于将宿主受体插入免疫球蛋白基因的新的多样化机制，从而导致产生受体-抗体。这些进步为疫苗设计和被动抗体疗法提供新的可能性，以提供杀菌免疫力并控制血液阶段的寄生虫。