During development innate lymphoid cells and specialized lymphocyte subsets colonize peripheral tissues, where they contribute to organogenesis and later constitute the first line of protection while maintaining tissue homeostasis. A few of these subsets are produced only during embryonic development and remain in the tissues throughout life. They are generated through a unique developmental program initiated in lympho-myeloid-primed progenitors, which lose myeloid and B cell potential. They either differentiate into innate lymphoid cells or migrate to the thymus to give rise to embryonic T cell receptor-invariant T cells. At later developmental stages, adaptive T lymphocytes are derived from lympho-myeloid progenitors that colonize the thymus, while lymphoid progenitors become specialized in the production of B cells. This sequence of events highlights the requirement for stratification in the establishment of immune functions that determine efficient seeding of peripheral tissues by a limited number of cells.

中文翻译：

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免疫细胞发育的新分子洞察。

在发育过程中，先天淋巴样细胞和专门的淋巴细胞亚群定植在周围组织中，在那里它们有助于器官发生，并随后在保持组织稳态的同时构成第一道保护线。这些子集中的一些仅在胚胎发育过程中产生，并在一生中保留在组织中。它们是通过独特的发育程序生成的，该程序是在淋巴细胞样髓系引发的祖细胞中启动的，该程序失去了髓样和B细胞的潜能。它们要么分化成先天性淋巴样细胞，要么迁移到胸腺，产生胚胎T细胞受体不变性T细胞。在以后的发育阶段，适应性T淋巴细胞来源于定殖在胸腺的淋巴髓样祖细胞，而淋巴样祖细胞则专门用于B细胞的生产。