npj Regenerative Medicine ( IF 6.4 ) Pub Date : 2019-04-26 , DOI: 10.1038/s41536-019-0071-x Ilja L Kruglikov 1 , Philipp E Scherer 2
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Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.
中文翻译：
Caveolin-1作为预防和治疗增生性疤痕的靶点
Caveolin-1 (Cav-1) 表达减少是肥厚性疤痕 (HTS) 的重要致病因素。这种减少与已知的 HTS 主要危险因素有关，包括深色皮肤、女性、年轻、烧伤部位和受伤严重程度。与 HTS 不同治疗方案相关的 Cav-1 过表达程度与 HTS 的临床改善相关。这使得Cav-1的内源或外源诱导不仅成为HTS的重要治疗靶点，而且凸显了其作为减少或避免HTS形成的预防靶点的用途。
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