Most cellular processes descend into failure during aging. While a large collection of longevity pathways has been identified in the past decades, the mechanism for age-related decline of cellular homeostasis and organelle function remains largely unsolved. It is known that many organelles undergo structural and functional changes during normal aging, which significantly contributes to the decline of tissue function at old ages. Since recent studies have revealed an emerging role of organelles as regulatory hubs in maintaining cellular homeostasis, understanding of organelle aging will provide important insights into the cellular basis of organismal aging. Here we review current progress on the characterization of age-dependent structural and functional alterations in the more well-studied organelles, as well as the known mechanisms governing organelle aging in model organisms, with a special focus on the fruit fly Drosophila melanogaster.

大多数细胞过程会在老化过程中失效。尽管在过去的几十年中已经确定了许多长寿途径，但与年龄相关的细胞稳态和细胞器功能下降的机制仍未得到解决。众所周知，许多细胞器在正常衰老过程中会发生结构和功能的变化，这在很大程度上导致了老年人组织功能的下降。由于最近的研究表明细胞器在维持细胞稳态中起着调节枢纽的作用，因此对细胞器衰老的了解将为了解生物衰老的细胞基础提供重要见解。在这里，我们将对在研究得更为深入的细胞器中与年龄相关的结构和功能改变的特征进行综述，果蝇。