Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.,Advanced Materials

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Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-04-24 , DOI: 10.1002/adma.201805798
Jie Gao ₁ , Jie Zhan ₁ , Zhimou Yang _{1,

2}

Affiliation

Self-assembly is a powerful tool for constructing supramolecular materials for many applications, ranging from energy harvesting to biomedicine. Among the methods to prepare supramolecular materials for biomedical applications, enzyme-instructed self-assembly (EISA) has several advantages. Herein, the unique properties and advantages of EISA in preparing biofunctional supramolecular nanomaterials and hydrogels from peptides are highlighted. EISA can trigger molecular self-assembly in situ. Therefore, using overexpression enzymes in disease sites, supramolecular materials can be formed in situ to improve the selectivity and efficacy of the treatment. The precursor may be involved during the EISA process, and it is actually a two-component self-assembly process. The precursor can help to stabilize the assembled nanostructures of hydrophobic peptides formed by EISA. More importantly, the precursor may determine the outcome of molecular self-assembly. Recently, it was also observed that EISA can kinetically control the peptide folding and morphology and cellular uptake behavior of supramolecular nanomaterials. With the combination of other methods to trigger molecular self-assembly, researchers can form supramolecular nanomaterials in a more precise mode and sometimes under spatiotemporal control. EISA is a powerful and unique methodology to prepare supramolecular biofunctional materials that cannot be generated from other common methods.

中文翻译：

酶指导的自组装（EISA）和肽的水凝胶化。

自组装是构建超分子材料的强大工具，可用于从能量收集到生物医学的许多应用。在制备用于生物医学应用的超分子材料的方法中，酶指导的自组装（EISA）具有多个优点。在本文中，突出了EISA在从肽制备生物功能超分子纳米材料和水凝胶中的独特性质和优势。EISA可以原位触发分子自组装。因此，在疾病部位使用过表达酶，可以在原位形成超分子材料，以提高治疗的选择性和功效。在EISA过程中可能涉及到前体，实际上它是一个两组分的自组装过程。前体可以帮助稳定由EISA形成的疏水肽的组装纳米结构。更重要的是，前体可以决定分子自组装的结果。最近，还观察到EISA可以动力学控制超分子纳米材料的肽折叠，形态和细胞摄取行为。结合其他触发分子自组装的方法，研究人员可以以更精确的方式，有时在时空的控制下形成超分子纳米材料。EISA是一种制备超分子生物功能材料的强大而独特的方法，而超分子生物功能材料是无法通过其他常见方法生成的。还观察到EISA可以动力学控制超分子纳米材料的肽折叠和形态以及细胞摄取行为。结合其他触发分子自组装的方法，研究人员可以以更精确的方式，有时在时空的控制下形成超分子纳米材料。EISA是一种制备超分子生物功能材料的强大而独特的方法，而超分子生物功能材料是无法通过其他常见方法生成的。还观察到EISA可以动力学控制超分子纳米材料的肽折叠和形态以及细胞摄取行为。结合其他触发分子自组装的方法，研究人员可以以更精确的方式，有时在时空的控制下形成超分子纳米材料。EISA是一种制备超分子生物功能材料的强大而独特的方法，而超分子生物功能材料是无法通过其他常见方法生成的。

更新日期：2020-01-22

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