A thorough understanding of the cognitive effects of antidepressant medications is essential given their frequency of use. This meta-analysis was conducted to investigate whether antidepressants differentially affect the various domains of cognitive functioning for depressed and non-depressed participants. An electronic search of PsycInfo, Medline and Google Scholar was conducted for all journal articles published between January 1998 and January 2017. Thirty-three studies were included enabling calculation of Hedges’ g using a random effects model for the cognitive domains of divided attention, executive function, expressive language, immediate memory, perceptual motor skills, processing speed, recent memory, sustained attention, visuospatial-constructional skills and working memory. Results revealed that overall, antidepressants have a modest, positive effect on divided attention, executive function, immediate memory, processing speed, recent memory and sustained attention for depressed participants. Selective serotonin reuptake inhibitors (SSRI’s) were found to have the greatest positive effect on cognition for depressed participants, as compared to the other classes of antidepressants analysed. Antidepressants did not significantly affect cognitive function in non-depressed participants.

中文翻译：

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对抑郁症和非抑郁症患者抗抑郁药对认知功能的影响的荟萃分析

考虑到抗抑郁药的使用频率，必须对抗抑郁药的认知作用有透彻的了解。进行了这项荟萃分析，以研究抗抑郁药是否对抑郁症和非抑郁症参与者的认知功能的各个领域产生不同的影响。对1998年1月至2017年1月之间发表的所有期刊文章进行了PsycInfo，Medline和Google Scholar的电子搜索。其中包括33项研究，可计算对冲的g使用随机效应模型对注意力分散的认知领域，执行功能，表达语言，即时记忆，知觉运动技能，处理速度，近期记忆，持续注意力，视觉空间构造技能和工作记忆进行认知。结果显示，总体而言，抗抑郁药对抑郁的参与者的注意力分散，执行功能，即时记忆，处理速度，近期记忆和持续注意力有中等程度的积极影响。与分析的其他类型的抗抑郁药相比，发现选择性5-羟色胺再摄取抑制剂（SSRI's）对抑郁症参与者的认知具有最大的积极作用。抗抑郁药没有显着影响非抑郁参与者的认知功能。