The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.

中文翻译：

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多酚通过靶向p53信号通路的抗癌作用：最新进展和未来方向。

多酚的抗癌作用归因于几种信号传导途径，包括肿瘤抑制基因肿瘤蛋白53（p53）。内源性p53的表达在各种类型的癌症中都是沉默的。来自多种饮食来源的多种多酚可通过不同的作用机制上调几种癌细胞系中的p53表达。这篇综述的目的是关注p53信号通路的重要性，并通过监测在肿瘤抑制中具有重要作用的p53表达来提供饮食中多酚在化学预防中的分子直觉。