Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.

中文翻译：

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Interleukin-1 和相关细胞因子在炎症和免疫调节中的作用。

在其命名四十年后，白细胞介素-1 (IL-1) 正在经历一场复兴，这是由于对其背景依赖性作用的日益了解和临床进展而带来的。最近的研究已经确定了 IL-1 家族成员（IL-18、IL-33、IL-36、IL-37 和 IL-38）在炎症和免疫中的重要作用。在这里，我们回顾了 IL-1 家族成员在协调先天性和适应性免疫反应中的复杂功能及其多样性和可塑性。我们讨论了 IL-1 家族成员在免疫稳态中的不同作用及其对病理学的贡献，包括自身免疫和自身炎症、代谢障碍、心血管疾病和癌症。抗 IL-1 策略的跨疾病治疗活性将免疫和炎症视为现代医学的元叙事。