The common cytokine receptor γ chain, γ_c, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ_c results in X-linked severe combined immunodeficiency in humans, and γ_c family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. Here, we review the basic biology of these cytokines, highlighting mechanisms of signaling and gene regulation that have provided insights for immunodeficiency, autoimmunity, allergic diseases, and cancer. Moreover, we discuss how studies of this family stimulated the development of JAK3 inhibitors and present an overview of current strategies targeting these pathways in the clinic, including novel antibodies, antagonists, and partial agonists. The diverse roles of these cytokines on a range of immune cells have important therapeutic implications.

常见的细胞因子受体γ链，γ _Ç，是受体的一个组件，其用于白介素-2（IL-2），IL-4，IL-7，IL-9，IL-15，和IL-21。编码γ基因的突变_Ç在结果中X-连锁在人类严重联合免疫缺陷，和γ _Ç家庭细胞因子共同调节免疫细胞的发育，增殖，存活和分化。在这里，我们回顾了这些细胞因子的基本生物学，重点介绍了信号传导和基因调控的机制，这些机制为免疫缺陷，自身免疫，过敏性疾病和癌症提供了见识。此外，我们讨论了该家族的研究如何刺激JAK3抑制剂的发展，并概述了针对这些临床途径的当前策略的概述，包括新型抗体，拮抗剂和部分激动剂。这些细胞因子在多种免疫细胞上的不同作用具有重要的治疗意义。