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An X-ray Vision for Phosphoantigen Recognition
Immunity ( IF 25.5 ) Pub Date : 2019-04-16 , DOI: 10.1016/j.immuni.2019.03.015
Michael L. Dustin , Emmanuel Scotet , Daniel Olive

Invariant Vγ9Vδ2 T cells respond to “phosphoantigen” metabolites through binding to the B30.2 domain of butyrophilin BTN3A. Yang et al. (2019) use molecular dynamic simulations based on X-ray structures of distinct B30.2 domain dimers to identify the asymmetric dimer as most active, which has implications for the inside-out signaling mechanism.



中文翻译:

磷抗原识别的X射线视觉

不变的Vγ9Vδ2T细胞通过与嗜丁菌素BTN3A的B30.2结构域结合而对“磷酸抗原”代谢产物作出反应。杨等。(2019)使用基于不同B30.2域二聚体的X射线结构的分子动力学模拟,将不对称二聚体确定为最活跃的,这对由内而外的信号传导机制具有影响。

更新日期:2019-04-16
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