Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.

中文翻译：

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在溃疡性结肠炎中暴露17型炎症。

溃疡性结肠炎的全基因组关联研究指出，FcγRIIA是IgG的受体。卡斯特罗-多皮科（Castro-Dopico）等。（2019）发现UC患者结肠粘膜中抗共生IgG的深刻诱导，并概述了IgG激活FcγR激活IL-1β产生，17型免疫和加剧炎症的途径。