Syphilis is caused by infection with the spirochetal bacterium Treponema pallidum subsp. pallidum. It was first recognized in the late 15th century. Since 2000, the incidence of sexually acquired syphilis has increased substantially in the developed world, with men who have sex with men and persons living with HIV infection disproportionately affected. Clinical manifestations of syphilis are protean and often include mucocutaneous manifestations. The first article in this continuing medical education series reviews historical aspects, microbiology, epidemiology, and clinical manifestations of sexually acquired syphilis.

中文翻译：

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性获得性梅毒：历史，微生物学，流行病学和临床表现。

梅毒是由螺旋体螺旋体梅毒螺旋体亚种感染引起的。苍白的。它在15世纪后期首次被认可。自2000年以来，在发达国家，性获得性梅毒的发病率已大大增加，与男性发生性关系的男性和感染艾滋病毒的人受到的影响尤其严重。梅毒的临床表现是蛋白质，通常包括粘膜皮肤表现。该继续医学教育系列的第一篇文章回顾了性获得性梅毒的历史，微生物学，流行病学和临床表现。