The methods used for the laboratory diagnosis of syphilis include direct detection of Treponema pallidum subspecies pallidum and serologic testing. Serologic testing relies on both nontreponemal and treponemal tests. In newly developed reverse-sequence screening algorithms, treponemal tests are performed before nontreponemal tests. The management of syphilis requires appropriate staging, treatment, and follow-up of patients along with the prompt reporting of infections to public health authorities to assist with prevention and control efforts. Benzathine penicillin G remains the treatment of choice for all stages of syphilis. Screening of populations at higher risk for syphilis is recommended by the US Centers for Disease Control and Prevention, the US Preventive Services Task Force, and the World Health Organization. The second article in this continuing medical education series reviews the testing for and the management of sexually acquired syphilis.

中文翻译：

---

性获得性梅毒：实验室诊断，管理和预防。

用于梅毒实验室诊断的方法包括直接检测梅毒螺旋体亚种苍白球和血清学检测。血清学检查依赖于非梅毒和梅毒测试。在新开发的反向序列筛选算法中，在进行非梯形检测之前先进行筛形检测。梅毒的管理需要对患者进行适当的分期，治疗和随访，并及时向公共卫生部门报告感染情况，以协助进行预防和控制工作。苄星青霉素G仍然是梅毒所有阶段的首选治疗方法。美国疾病控制与预防中心，美国预防服务工作队和世界卫生组织建议对梅毒风险较高的人群进行筛查。