With recent advances in computational modeling and in situ transmission electron microscopy (TEM) technologies, there have been increased efforts to apply these approaches to understand defect-based mechanisms dictating deformation mechanics. In situ TEM experiments and atomistic simulations each have their own unique limitations, including observable length and time scales and accessibility of information, motivating approaches that combine the two approaches. In this paper, we review recent studies that combine atomistic simulations and in situ TEM experiments to understand defect mechanisms associated with deformation of metals and alloys. In addition, we discuss ongoing developments in characterization and simulation capabilities that are expected to significantly advance the field of defect mechanics and allow greater integration between atomistic simulations and in situ TEM experiments.

随着计算建模和原位透射电子显微镜（TEM）技术的最新进展，人们加大了应用这些方法来理解决定变形力学的基于缺陷的机制的努力。原位TEM实验和原子模拟各自都有其独特的局限性，包括可观察到的长度和时间范围以及信息的可访问性，从而激发了将这两种方法结合起来的方法。在本文中，我们回顾了结合了原子模拟和原位模拟的最新研究TEM实验可了解与金属和合金变形相关的缺陷机理。此外，我们讨论了表征和仿真功能的不断发展，这些开发有望显着推进缺陷力学领域，并允许原子模拟与原位TEM实验之间实现更大的集成。