Erectile dysfunction (ED) is an important complication of diabetes. The aim of our study was to determine whether Ferula elaeochytris (FE) root extract could affect ED in streptozotocin (STZ)-induced diabetic rats. Seventy-five adult male Wistar albino rats were equally divided into five groups; control (C), FE (40 mg/kg-d), STZ-induced diabetes (60 mg/kg) (DM), diabetes + F. elaeochytris (DM + FE), and ethanol (EtOH). After 8 weeks, in vitro and in vivo parameters (intracavernosal pressure [ICP]), testicle and body weight, serum glucose levels, and histopathology were assessed. In the STZ-induced diabetic group, acetylcholine-induced endothelium-dependent relaxation responses, and electrical field stimulation-induced neurogenic and nitrergic relaxation responses were decreased significantly, while FE administration to diabetic rats reversed the decreased nitrergic and neurogenic responses. In the diabetic group, ICP/MAP (0.1375 ± 0.02 cm/H₂O), spermatogenesis in testicles (53.73 ± 0.81), and testicle weights (257.8 ± 20.63) were decreased significantly; however, FE administration to diabetic rats restored the decreased values (0.350 ± 0.019 cm/H₂O, 75.07 ± 0.35, and 416 ± 24.11, respectively). In the DM group, blood glucose levels were increased (411.7 ± 18.30) compared to the C group. However, FE administration to diabetic rats reduced glucose levels (230.6 ± 25.60 mg/dL) compared to the DM group. In conclusion, FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats.

勃起功能障碍（ED）是糖尿病的重要并发症。我们研究的目的是确定Ferula elaeochytris（FE）根提取物是否会影响链脲佐菌素（STZ）诱导的糖尿病大鼠中的ED。将75只成年雄性Wistar白化病大鼠平均分为5组；每组5只。对照组（C），FE（40 mg / kg-d），STZ诱导的糖尿病（60 mg / kg）（DM），糖尿病+  F。棘皮动物（DM + FE）和乙醇（EtOH）。8周后，评估了体内和体外参数（腹膜内气压[ICP]），睾丸和体重，血清葡萄糖水平以及组织病理学。在STZ诱导的糖尿病组中，乙酰胆碱诱导的内皮依赖性舒张反应以及电场刺激诱导的神经原性和亚硝酸盐松弛反应均显着降低，而给予糖尿病大鼠的FE则逆转了降低的硝化和神经源性反应。糖尿病组的ICP / MAP（0.1375±0.02 cm / H ₂ O），睾丸生精（53.73±0.81）和睾丸重量（257.8±20.63）显着降低。但是，对糖尿病大鼠进行FE补充可恢复降低的值（0.350±0.019 cm / H ₂分别为O，75.07±0.35和416±24.11）。与C组相比，DM组的血糖水平升高（411.7±18.30）。但是，与DM组相比，对糖尿病大鼠进行FE给药可降低葡萄糖水平（230.6±25.60 mg / dL）。总之，FE可恢复糖尿病大鼠的神经源性和内皮功能障碍，并降低葡萄糖水平。