Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Strategies to avoid drug metabolism, overcome physiological barriers and achieve higher concentration at cancer sites through skin, buccal, nasal, vaginal, pulmonary and colon targeted delivery are presented. Current limitations, challenges and future research directions are also discussed.

天然化合物具有显着的抗癌药理活性，但经常遭受生物利用度和选择性低的问题，从而限制了治疗用途。本工作批判性地分析了旨在增强药代动力学，靶向，细胞摄取和抗癌植物成分的功效的药物递送系统的最新进展。脂质体，纳米颗粒，纳米乳剂和薄膜所携带的各种植物化学物质，包括类黄酮，白藜芦醇，celastrol，姜黄素，小ber碱和喜树碱，都显示出令人鼓舞的结果。提出了避免药物代谢，克服生理障碍并通过皮肤，颊，鼻，阴道，肺和结肠靶向递送在癌症部位达到更高浓度的策略。还讨论了当前的局限性，挑战和未来的研究方向。