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Chromatin dynamics during liver regeneration.
Seminars in Cell & Developmental Biology ( IF 6.2 ) Pub Date : 2019-04-09 , DOI: 10.1016/j.semcdb.2019.03.004
Maria Arechederra 1 , Carmen Berasain 2 , Matias A Avila 2 , Maite G Fernández-Barrena 2
Affiliation  

Liver regeneration is the most important reaction of the liver to an injury. Indeed, the liver possesses an extraordinary regenerative capacity orchestrated by a highly coordinated response of all the different cell types in order to recover the tissue lost, while maintaining homeostasis and all the hepatic functions. To achieve this impressive physiological accomplishment, the liver experiences a transient but precisely controlled transcriptional reprogramming that allows the simultaneous activation and silencing of multiple genes at different stages of the regeneration process. Epigenetic events play a fundamental role in the organization of chromatin architecture and hence in the tight control of gene transcription. In this review, we will summarize the most relevant epigenetic modifications associated with the critical changes in gene expression and cellular behavior occurring during liver regeneration. We will discuss the relevance of DNA methylation, histone modifications, and chromatin remodelers, and the interplay between these epigenetic events, during the regeneration process, mainly after partial hepatectomy or after chemical injury.

中文翻译:

肝脏再生过程中的染色质动力学。

肝再生是肝脏对损伤最重要的反应。确实,肝脏具有非凡的再生能力,这是由所有不同细胞类型的高度协调反应所协调形成的,以便恢复失去的组织,同时保持体内平衡和所有肝功能。为了获得令人印象深刻的生理学成就,肝脏经历了短暂但精确控制的转录重编程,从而允许在再生过程的不同阶段同时激活和沉默多个基因。表观遗传事件在染色质结构的组织中并因此在基因转录的严格控制中起着基本作用。在这篇评论中,我们将总结与肝脏再生期间发生的基因表达和细胞行为的关键变化相关的最相关的表观遗传修饰。我们将讨论DNA甲基化,组蛋白修饰和染色质重塑剂的相关性,以及这些表观遗传事件之间在再生过程中(主要是在部分肝切除术后或化学损伤后)之间的相互作用。
更新日期:2019-04-09
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