BACKGROUND The objective of the study is to evaluate the prospective associations between antioxidant intake and incident frailty among older Australian men aged ≥75 years. METHODS Seven hundred and ninety-four men participated in a detailed diet history interview at the Concord Health and Ageing in Men Project (CHAMP) study third wave (considered baseline nutrition here) and 781 men participated at the fourth wave (considered 3-year follow-up here). The main outcome measurement was incident frailty at 3-year follow-up, using the Cardiovascular Health Study definition. Dietary adequacy of antioxidant intake was assessed by comparing participants' median intakes of four dietary antioxidants (vitamin A, E, C, and zinc) to the nutrient reference values (NRVs). Attainment of the NRVs was incorporated into a dichotomized variable "poor" (meeting ≤2 antioxidants) or "good" (meeting ≥3 antioxidants) as the independent variable using the cut-point method. Also, intakes of each individual dietary antioxidant at baseline nutrition were categorized into quartiles. Analyses were performed using multinomial logistic regression. RESULTS Incidence of pre-frailty was 53.0% and frailty was 6.4% at 3-year follow-up. Poor dietary antioxidant intake (meeting ≤2) at baseline nutrition was associated with incident frailty at 3-year follow-up in unadjusted (OR: 2.59 [95% CI: 1.47, 4.59, p = .001]) and adjusted (OR: 2.46 [95% CI: 1.10, 5.51, p = .03]) analyses. The lowest quartile of vitamin E intake (<7.08 mg/d) was significantly associated with incident frailty (OR: 2.46 [95% CI: 1.01, 6.00, p = .05]). CONCLUSIONS Poor antioxidant intake, particularly vitamin E, is a plausible factor associated with incident frailty among older men. This supports the need for clinical trials of diets rich in antioxidants or possibly low-dose antioxidant supplements, for prevention of frailty.

中文翻译：

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澳大利亚老年男性饮食中抗氧化剂摄入量与虚弱之间的前瞻性关联：“男性健康与衰老的协调一致”项目。

背景技术本研究的目的是评估年龄≥75岁的澳大利亚老年男性中抗氧化剂的摄入与脆弱性之间的前瞻性关联。方法794名男性参加了“康科德男性健康与老化项目”（CHAMP）的详细饮食史访谈，研究了第三波（此处考虑了基线营养），781名男性参加了第四波（考虑了3年随访） -上面这儿）。根据心血管健康研究的定义，主要结局指标是随访3年的事件虚弱。通过将参与者的四种饮食抗氧化剂（维生素A，E，C和锌）的中位数摄入与营养参考值（NRV）进行比较，来评估饮食中抗氧化剂摄入的充足性。NRV的获得被合并为二分变量“贫穷” 使用切点法作为自变量（等于或小于等于2的抗氧化剂）或“好的”（等于或大于等于3的抗氧化剂）作为自变量。同样，在基线营养水平下每种饮食抗氧化剂的摄入量也被分类为四分位数。使用多项逻辑回归进行分析。结果在3年的随访中，身体虚弱的发生率为53.0％，身体虚弱的发生率为6.4％。在未经调整（OR：2.59 [95％CI：1.47，4.59，p = .001]）和调整后（OR： 2.46 [95％CI：1.10，5.51，p = .03]分析。维生素E摄入量最低的四分位数（<7.08 mg / d）与突发性体弱显着相关（OR：2.46 [95％CI：1.01、6.00，p = .05]）。结论抗氧化剂摄入不足，尤其是维生素E，这是与老年男性事件虚弱相关的合理因素。这支持对富含抗氧化剂或可能低剂量抗氧化剂的饮食进行临床试验的需要，以防止身体虚弱。