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Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
Annual Review of Physiology ( IF 15.7 ) Pub Date : 2018-02-12 00:00:00 , DOI: 10.1146/annurev-physiol-021317-121454
Magda R. Hamczyk 1, 2 , Lara del Campo 1, 2 , Vicente Andrés 1, 2
Affiliation  

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin. Progerin causes extensive atherosclerosis and cardiac electrophysiological alterations that invariably lead to premature aging and death. This review summarizes the main structural and functional alterations to the cardiovascular system during physiological and premature aging and discusses the mechanisms underlying exaggerated CVD and aging induced by prelamin A and progerin. Because both proteins are expressed in normally aging non-HGPS individuals, and most hallmarks of normal aging occur in progeria, research on HGPS can identify mechanisms underlying physiological aging.

中文翻译:


心血管系统中的衰老:Hutchinson-Gilford早衰综合症的经验教训

衰老是心血管疾病(CVD)的主要危险因素,在我们的社会中正越来越普遍。因此,迫切需要更好地了解衰老如何促进CVD,从而开发出减轻疾病负担的新策略。动脉粥样硬化和心力衰竭是与年龄相关的CVD相关死亡率的重要因素。患有Hutchinson-Gilford早衰综合症(HGPS)的患者均会加速CVD和衰老,HGPS是由prelamin A突变体progerin引起的罕见遗传疾病。早春素引起广泛的动脉粥样硬化和心脏电生理改变,总是导致过早衰老和死亡。这篇综述总结了生理和早衰过程中心血管系统的主要结构和功能改变,并讨论了由prelamin A和progerin引起的过度CVD和衰老的机制。由于两种蛋白质均在正常衰老的非HGPS个体中表达,并且大多数正常衰老的标志都出现在早衰症中,因此对HGPS的研究可以确定生理衰老的潜在机制。

更新日期:2018-02-12
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