Peripheral serotonin continuously reveals its unexpected involvements in many organ functions. In bone tissue, there is an increasing evidence for a local serotonergic system affecting the cellular and molecular actors involved in bone turnover. During orthodontic treatment, tooth movement relies on bone remodeling, itself a result of the inflammatory process triggered by application of orthodontic forces to the teeth. Nowadays, many adults proceed to an orthodontic treatment, it therefore seems important to consider physiological growth-related factors and external factors as medications that may influence adverse effects and efficacy of orthodontic treatment techniques. In this review, we focus on peripheral serotonin mechanism of regulation of bone remodeling during orthodontic movement. We discuss the differential effect of serotonin on alveolar bone inflammation that may open new strategies in orthodontics.

外周血清素不断地揭示其在许多器官功能中的出乎意料的作用。在骨组织中，越来越多的证据表明局部血清素能系统会影响参与骨转换的细胞和分子参与者。在正畸治疗期间，牙齿运动依赖于骨骼重塑，骨骼本身是由于在牙齿上施加正畸力而触发的炎症过程的结果。如今，许多成年人开始进行正畸治疗，因此，将与生理生长相关的因素和外部因素考虑为可能影响正畸治疗技术的不良影响和功效的药物似乎很重要。在这篇综述中，我们集中在牙齿矫正运动过程中调节骨骼重塑的外周血清素机制上。