The mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a therapeutic target, and explores clinical trials targeting the mTOR pathway in HCC. Although the review focuses on the mTOR pathway involved in HCC, more comprehensive discussions (eg, developing a rational design for future trials targeting the mTOR pathway) are also applicable to other tumors.

雷帕霉素（mTOR）途径的机械靶标可响应生长因子，营养素和细胞能量阶段来协调生物生长和体内稳态。该途径调节几种主要的细胞过程，并涉及各种病理状况，包括肝细胞癌（HCC）。这篇综述总结了mTOR途径的最新进展，强调了mTOR途径作为治疗靶标的潜力，并探讨了针对mCC途径在肝癌中的临床试验。尽管综述的重点是肝癌中涉及的mTOR途径，但更全面的讨论（例如，开发针对mTOR途径的未来试验的合理设计）也适用于其他肿瘤。