Mental health and well-being are consistently influenced-directly or indirectly-by multiple environmental exposures. In this review, we have attempted to address some of the most common exposures of the biophysical environment, with a goal of demonstrating how those factors interact with central structures and functions of the brain and thus influence the neurobiology of depression. We emphasize biochemical mechanisms, observational evidence, and areas for future research. Finally, we include aspects of contextual environments-city living, nature, natural disasters, and climate change-and call for improved integration of environmental issues in public health science, policies, and activities. This integration is necessary for reducing the global pandemic of depression.

中文翻译：

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环境暴露与抑郁：生物学机制和流行病学证据。

心理健康和福祉一直受到多种环境暴露的直接或间接影响。在这篇综述中，我们试图解决一些生物物理环境中最常见的暴露问题，目的是证明这些因素如何与大脑的中枢结构和功能相互作用，从而影响抑郁症的神经生物学。我们强调生化机制，观察证据以及未来研究的领域。最后，我们包括背景环境的各个方面-城市生活，自然，自然灾害和气候变化-并呼吁将环境问题更好地整合到公共卫生科学，政策和活动中。这种整合对于减少全球抑郁症大流行是必要的。