In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.

中文翻译：

---

基于相关性的代谢组学鉴定水仙子素为拟南芥的体外抗炎成分。

在这项研究中，来自贯叶连翘的鳞茎提取物在体外显示出很强的抗炎活性。将提取物部分分为14个部分，并通过超高效液相色谱-四极杆飞行时间质谱代谢组学进行分析，并计算生物活性与代谢物水平之间的相关系数。结果，提出了得分最高的代谢产物水仙子素（1）作为合同小球藻的有效成分。通过将粗提物的生物效应与真实标准品的生物效应进行比较，可以证实这一点。