Design Multi-centre split mouth randomised controlled trial.

Intervention Following prophylaxis, isolation, etching and drying the allocated resin-based fissure sealant (RBS) was applied according to the manufacturer's instructions. Reviews were undertaken by a blinded observer at 6,12,18 and 24 months. Operators and observers were calibrated for ICDAS .

Outcome measure The primary outcome was the presence of an ICDAS (International Caries Detection and Assessment System) 3-6 lesion on sealed tooth during the two-year follow-up. Sealant retention was a secondary outcome.

Results Four hundred children (663 tooth pairs) were randomised, 290 children (483 tooth pairs) completed the two-year follow up. There was a lower risk of ICDAS 3-6 lesions in sealed molars; Hazard ratio [HR] = 0.16 (95% CI: 0.14 - 0.19). The effect was similar for both fluoride; HR= 0.15 (95% CI: 0.12 - 0.19) and non-fluoride sealants; HR= 0.18 (95% (CI: 0.15 - 0.21)

Conclusions Sealant placement reduced the risk of ICDAS 3-6 lesions at 24 months; similar reductions in caries were seen for fluoride and non-fluoride sealants.

设计多中心裂口随机对照试验。

干预预防，隔离，蚀刻和干燥分配的树脂基裂缝密封剂（RBS）后，按照制造商的说明进行。盲人观察员在6,12,18和24个月进行了审查。操作员和观察员已针对ICDAS进行了校准。

结果测量两年的随访期间，主要结果是密封牙齿上存在ICDAS（国际龋齿检测和评估系统）3-6病变。密封剂保留是次要结果。

结果对400名儿童（663对牙齿）进行了随机分组，其中290名儿童（483对牙齿）完成了为期两年的随访。封闭磨牙中ICDAS 3-6病变的风险较低；危险比[HR] = 0.16（95％CI：0.14-0.19）。两种氟化物的作用相似。HR = 0.15（95％CI：0.12-0.19）和无氟密封胶; HR = 0.18（95％（CI：0.15-0.21）

结论放置密封剂可以降低24个月ICDAS 3-6病变的风险; 氟化物和非氟化物密封剂的龋齿也有类似的减少。