Phosphoinositides are a group of lipids that regulate intracellular signaling and subcellular biological events. The signaling by phosphatidylinositol-3,4,5-trisphosphate and Akt mediates the action of growth factors that are essential for cell proliferation, gene transcription, cell migration, and polarity. The hyperactivation of this signaling has been identified in different cancer cells; and, it has been implicated in oncogenic transformation and cancer cell malignancy. Recent studies have argued the role of phosphoinositides in cancer cell dynamics, including actin cytoskeletal rearrangement at the plasma membrane and the organization of intracellular compartments. The focus of this review is to summarize the impact of the activities of phosphoinositide phosphatases on intracellular signaling related to cancer cell dynamics and to discuss how the abnormalities in the activities of the enzymes alter the levels of phosphoinositides in cancer cells.

磷酸肌醇是调节细胞内信号传导和亚细胞生物学事件的一组脂质。磷脂酰肌醇-3,4,5-三磷酸和Akt发出的信号介导了生长因子的作用，这些生长因子对于细胞增殖，基因转录，细胞迁移和极性至关重要。已经在不同的癌细胞中发现了这种信号的过度激活。并且，它与致癌转化和癌细胞恶性肿瘤有关。最近的研究争论了磷酸肌醇在癌细胞动力学中的作用，包括质膜上的肌动蛋白细胞骨架重排和细胞内区室的组织。