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Comparative quality of the forms of decoction pieces evaluated by multidimensional chemical analysis and chemometrics: Poria cocos, a pilot study
Journal of Food and Drug Analysis ( IF 2.6 ) Pub Date : 2019-07-01 , DOI: 10.1016/j.jfda.2019.03.002 Li-Xia Zhu 1, 2 , Jun Xu 1 , Yun Wu 3 , Li-Fei Su 3 , Kelly Yin Ching Lam 1 , Elizabeth R Qi 1 , Xiao-Ping Dong 1, 2 , Hu-Biao Chen 1 , Yu-De Liu 3 , Zhong-Zhen Zhao 1
Journal of Food and Drug Analysis ( IF 2.6 ) Pub Date : 2019-07-01 , DOI: 10.1016/j.jfda.2019.03.002 Li-Xia Zhu 1, 2 , Jun Xu 1 , Yun Wu 3 , Li-Fei Su 3 , Kelly Yin Ching Lam 1 , Elizabeth R Qi 1 , Xiao-Ping Dong 1, 2 , Hu-Biao Chen 1 , Yu-De Liu 3 , Zhong-Zhen Zhao 1
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Many Chinese medicinal materials (CMMs) are parts of plants or fungi that have been processed into different physical forms, termed decoction pieces, that are typically boiled in water for consumption. One CMM may have several decoction pieces forms, e.g., slices, small cubes (dice), or grains. The specifications that have different morphological parameters (shape, size and thickness) for these various decoction pieces have been developed over, in some cases, centuries of practice. Nevertheless, whether and how the form of decoction pieces affects the extraction (decoction) dynamics, and quality stability during storage has not been studied. Here, we investigated Poria cocos (PC) as a pilot study; we explore how the form of PC decoction pieces affects its chemistry using multidimensional chemical evaluation such as ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometry (UHPLC-PDA-QTOF-MS/MS), ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance gel permeation chromatography coupled with charged aerosol detector (HPGPC-CAD), combined with analysis of variance (ANOVA), principal component analysis (PCA), factor analysis (FA) and hierarchical cluster analysis (HCA). The results indicated that different specifications had significant differences, and these specifications could be divided into four groups. The comprehensive results of the chemical analyses undertaken here indicate that the highest potentially available quality of PC decoction pieces was in the forms of curl, ultra-small grains and small grains, followed by thin slices. This information not only is conducive to promoting the standardization of the specification/form of PC decoction pieces and maximizing the benefits from its utilization, but also provide a promising strategy for assessing other CMM decoction pieces in different forms.
中文翻译：
通过多维化学分析和化学计量学评估的汤剂形式的比较质量：茯苓，一项初步研究
许多中药材 (CMM) 是植物或真菌的一部分，它们被加工成不同的物理形式，称为汤剂，通常在水中煮沸后食用。一个 CMM 可能有几种煎剂形式，例如切片、小方块（骰子）或谷物。这些不同的煎剂具有不同形态参数（形状、大小和厚度）的规格，在某些情况下，经过几个世纪的实践已经形成。然而，煎剂的形式是否以及如何影响提取（煎剂）动力学以及储存过程中的质量稳定性尚未研究。在这里，我们调查了茯苓（PC）作为试点研究；我们使用超高效液相色谱-光电二极管阵列-四极杆飞行时间质谱 (UHPLC-PDA-QTOF-MS/MS)、超高效液相色谱-三重四极杆质谱（UHPLC-QqQ-MS/MS）和高效凝胶渗透色谱结合带电气溶胶检测器（HPGPC-CAD），结合方差分析（ANOVA）、主成分分析（PCA）、因子分析（FA）和层次聚类分析（HCA）。结果表明，不同规格有显着差异，这些规格可分为四组。这里进行的化学分析的综合结果表明，PC 饮片的最高潜在质量是卷曲、超小颗粒和小颗粒的形式，其次是薄片。该信息不仅有利于促进中药饮片规格/形式的标准化，最大限度地发挥其利用效益，而且为评估其他不同形式的中药饮片提供了有前景的策略。
更新日期：2019-07-01
中文翻译：
通过多维化学分析和化学计量学评估的汤剂形式的比较质量：茯苓，一项初步研究
许多中药材 (CMM) 是植物或真菌的一部分，它们被加工成不同的物理形式，称为汤剂，通常在水中煮沸后食用。一个 CMM 可能有几种煎剂形式，例如切片、小方块（骰子）或谷物。这些不同的煎剂具有不同形态参数（形状、大小和厚度）的规格，在某些情况下，经过几个世纪的实践已经形成。然而，煎剂的形式是否以及如何影响提取（煎剂）动力学以及储存过程中的质量稳定性尚未研究。在这里，我们调查了茯苓（PC）作为试点研究；我们使用超高效液相色谱-光电二极管阵列-四极杆飞行时间质谱 (UHPLC-PDA-QTOF-MS/MS)、超高效液相色谱-三重四极杆质谱（UHPLC-QqQ-MS/MS）和高效凝胶渗透色谱结合带电气溶胶检测器（HPGPC-CAD），结合方差分析（ANOVA）、主成分分析（PCA）、因子分析（FA）和层次聚类分析（HCA）。结果表明，不同规格有显着差异，这些规格可分为四组。这里进行的化学分析的综合结果表明，PC 饮片的最高潜在质量是卷曲、超小颗粒和小颗粒的形式，其次是薄片。该信息不仅有利于促进中药饮片规格/形式的标准化，最大限度地发挥其利用效益，而且为评估其他不同形式的中药饮片提供了有前景的策略。
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