Committing to a differentiation pathway means leaving alternative pathways behind. Adoue et al. (2019) report that the H3K9-methyltrasferase Setdb1 plays a role in inhibiting the Th1 program in committed Th2 cells, and mechanistically, its role might relate to the selective targeting of endogenous retroviruses adjacent to Th1 enhancers.

中文翻译：

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定义阻碍选择的障碍

致力于差异化途径意味着抛弃其他途径。Adoue等。（2019）报告说，H3K9-甲基转移酶Setdb1在抑制定型Th2细胞中的Th1程序中发挥作用，并且从机理上讲，它的作用可能与选择性地靶向与Th1增强子相邻的内源性逆转录病毒有关。