当前位置: X-MOL 学术PLOS ONE › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Circulating interleukin-6 (IL-6) levels are associated with aortic dimensions in genetic aortic conditions.
PLOS ONE ( IF 2.9 ) Pub Date : 2019-03-18 , DOI: 10.1371/journal.pone.0214084
Daishi Fujita 1 , Liliana Preiss 2 , Kenichi Aizawa 1 , Federico Asch 3 , Kim Eagle 4 , Toru Suzuki 5, 6, 7 ,
Affiliation  

BACKGROUND Biomarkers that reflect progression of dilatation of the aorta in patients with aortic conditions are needed as surrogate tools to assist in monitoring the condition in a non-invasive manner in combination with imaging procedures. This study aimed to investigate whether biomarkers are associated with aortic dimensions in patients enrolled in the Genetically-Triggered Thoracic Aortic Conditions (GenTAC) registry. METHODS Plasma samples of 159 patients enrolled in the GenTAC registry were assessed for circulating biomarkers [interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), tissue inhibitor of metalloproteinase-2 (TIMP-2) and transforming growth factor-β1 (TGFβ1)]. Association of circulating biomarker levels with aortic dimensions was investigated. RESULTS IL-6 showed significant positive correlations with aortic dimensions at each segment of the aorta, with the correlation increasing in more distal aortic regions (ascending aorta, R = 0.26, p = 0.004; proximal arch, R = 0.35, p<0.0001; transverse arch, R = 0.30, p = 0.0005; mid-descending thoracic aorta, R = 0.40, p<0.0001; thoracoabdominal aorta, R = 0.38, p<0.0001; suprarenal abdominal aorta, R = 0.42, p<0.0001; and infrarenal aorta, R = 0.43, p<0.0001). TIMP-1 showed a significant correlation albeit weaker than IL-6, and also showed increasing correlation towards the distal areas of the aorta. CONCLUSIONS Circulating IL-6 and TIMP-1 were associated with aortic dimensions in patients with aortopathies enrolled in the GenTAC cohort.

中文翻译:

在遗传性主动脉疾病中,循环中的白介素6(IL-6)水平与主动脉尺寸有关。

背景技术需要反映出主动脉疾病患者的主动脉扩张进程的生物标志物作为替代工具,以辅助以无创方式结合成像程序监测疾病状态。这项研究旨在调查在遗传触发的胸主动脉疾病(GenTAC)注册中登记的患者中,生物标志物是否与主动脉大小相关。方法评估了GenTAC登记的159例患者的血浆样本中的循环生物标志物[白介素6(IL-6),基质金属蛋白酶9(MMP-9),金属蛋白酶1组织抑制剂(TIMP-1),组织抑制剂]。蛋白酶2(TIMP-2)和转化生长因子-β1(TGFβ1)的表达]。循环生物标志物水平与主动脉大小的关联进行了调查。结果IL-6在主动脉的每个节段显示与主动脉尺寸的显着正相关,并且在更多的远端主动脉区域中相关性增加(升主动脉,R = 0.26,p = 0.004;近端弓,R = 0.35,p <0.0001;主动脉弓,R = 0.35,p <0.0001;主动脉弓。横弓,R = 0.30,p = 0.0005;降中胸主动脉,R = 0.40,p <0.0001;胸腹主动脉,R = 0.38,p <0.0001;肾上腹主动脉,R = 0.42,p <0.0001;和肾下主动脉,R = 0.43,p <0.0001)。TIMP-1显示出显着的相关性,尽管比IL-6弱,并且还显示出与主动脉远端区域的相关性增加。结论GenTAC研究组的主动脉病变患者中,循环IL-6和TIMP-1与主动脉尺寸有关。在更多的远端主动脉区域中相关性增加(升主动脉,R = 0.26,p = 0.004;近端弓,R = 0.35,p <0.0001;横弓,R = 0.30,p = 0.0005;中降胸主动脉,R = 0.40,p <0.0001;胸腹主动脉,R = 0.38,p <0.0001;肾上腹主动脉,R = 0.42,p <0.0001;和肾下主动脉,R = 0.43,p <0.0001)。TIMP-1显示出显着的相关性,尽管比IL-6弱,并且还显示出与主动脉远端区域的相关性增加。结论GenTAC研究组的主动脉病变患者中,循环IL-6和TIMP-1与主动脉尺寸有关。在更多的远端主动脉区域中相关性增加(升主动脉,R = 0.26,p = 0.004;近端弓,R = 0.35,p <0.0001;横弓,R = 0.30,p = 0.0005;中降胸主动脉,R = 0.40,p <0.0001;胸腹主动脉,R = 0.38,p <0.0001;肾上腹主动脉,R = 0.42,p <0.0001;和肾下主动脉,R = 0.43,p <0.0001)。TIMP-1显示出显着的相关性,尽管比IL-6弱,并且还显示出与主动脉远端区域的相关性增加。结论GenTAC研究组的主动脉病变患者中,循环IL-6和TIMP-1与主动脉尺寸有关。40,p <0.0001; p <0.0001。胸腹主动脉,R = 0.38,p <0.0001;肾上腹主动脉,R = 0.42,p <0.0001; 和肾下主动脉,R = 0.43,p <0.0001)。TIMP-1显示出显着的相关性,尽管比IL-6弱,并且还显示出与主动脉远端区域的相关性增加。结论GenTAC研究组的主动脉病变患者中,循环IL-6和TIMP-1与主动脉尺寸有关。40,p <0.0001; p <0.0001。胸腹主动脉,R = 0.38,p <0.0001;肾上腹主动脉,R = 0.42,p <0.0001; 和肾下主动脉,R = 0.43,p <0.0001)。TIMP-1显示出显着的相关性,尽管比IL-6弱,并且还显示出与主动脉远端区域的相关性增加。结论GenTAC研究组的主动脉病变患者中,循环IL-6和TIMP-1与主动脉尺寸有关。
更新日期:2019-03-19
down
wechat
bug