Falls are frequent in Parkinson’s disease and aging. Impairments in the cholinergic-mediated attentional supervision of gait may contribute to increased fall risk, especially when obstacles challenge gait. Interventions combining motor-cognitive approaches have been shown to improve motor performance, cognitive skills, and falls number. Here, we hypothesized that an intervention simulating an attention-demanding walking condition could affect not only complex gait performance and fall risk but also short-latency afferent inhibition (SAI), as a marker of cholinergic activity.

中文翻译：

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多模式训练可调节短暂的抑制作用，并改善帕金森氏病患病率下降的成年老年人群中的复杂步行

帕金森氏病和衰老频繁发生。胆碱能介导的步态注意力监控中的障碍可能会导致跌倒风险增加，尤其是当障碍物挑战步态时。结合运动认知方法进行的干预已被证明可以改善运动表现，认知技能和摔倒次数。在这里，我们假设模拟需要注意的步行条件的干预措施不仅会影响复杂的步态表现和跌倒风险，而且还会影响作为胆碱能活动指标的短暂潜伏传入抑制（SAI）。